The driving distance is approximately 500-600 km, but the significant factor is the Channel crossing. You can choose between the Eurotunnel Le Shuttle (around 35 minutes crossing from Calais to Folkestone) or a ferry (e.g., Calais to Dover, Dunkirk to Dover, typically 1.5-2 hours sailing time). Tolls are primarily for the Channel crossing. Be aware of potential charges in London, such as the Congestion Charge and ULEZ (Ultra Low Emission Zone), which apply to most vehicles entering central London. Fuel costs are estimates and vary based on vehicle efficiency and fuel prices.