Direct bus connections from Athens to Rome are not practical without a ferry. Journeys often involve taking a bus from Athens to a Greek port (e.g., Igoumenitsa), a ferry to an Italian port (e.g., Bari), and then a connecting bus to Rome. Art Tour is mentioned for a bus-ferry combination via Durrës, taking approximately 19h 45m to 20h 27m. Bus services from Bari to Rome (e.g., FlixBus, Marozzi, Itabus) typically take 4.5-7 hours and cost EUR 10-44. The long FlixBus service of '52 hours' from Athens to Rome is usually by land around the Adriatic, which is highly impractical and not recommended.