The road distance is roughly 2,230 km to 3,800 km, depending on the route. The route would typically involve crossing multiple international borders, including potentially unstable regions such as Syria, which makes it unsafe and largely inaccessible for tourists. There are no specific tourist-oriented toll systems readily available for the entire route, though tolls exist in Turkey. Visa requirements for transit through various countries would also be extensive and complex. This option is generally not feasible for direct travel between Istanbul and Cairo.