The fastest route (I-5 N) covers approximately 380-400 miles and typically takes 6-7 hours without significant traffic or stops. The more scenic US-101 route is around 430 miles and takes longer (7-8 hours). Highway 1, while beautiful, is a much longer drive (450-500+ miles) and is best suited for a multi-day road trip. Typical fuel costs for a standard vehicle (approx. 25 MPG) can range from USD 60-100+, based on an average California gas price of USD 4.40-4.60 per gallon. There are no direct tolls on I-5 or US-101 between Los Angeles and San Francisco. However, tolls apply when crossing certain Bay Area bridges into San Francisco (e.g., Golden Gate Bridge southbound, Bay Bridge westbound). Express lanes in certain areas may also incur tolls.