The driving distance is approximately 2,780 to 2,800 miles. Key interstates often include I-80, I-70, or I-40, connecting various regions. Fuel costs are estimates based on average vehicle MPG and gas prices. Tolls can be encountered, particularly around the New York area, though toll-free routes are often available, potentially extending travel time. Planning for overnight stays and vehicle maintenance is essential for this extensive road trip.